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Theory of Candida and Antibiotic-Induced Dysbiosis Resulting in the Proliferation of Candida albicans as the Primary Cause of Leaky Gut [Otherwise Commonly Known as Candida Yeast Overgrowth] I think it is important to address the validity of a diagnosis, and quite often a self-diagnosis, of candida yeast overgrowth, candidiasis, chronic yeast infection, or candida hypersensitivity. Although vaginal yeast infections are common among people suffering from candidiasis, the kind of yeast infection we are talking about here is systemic, meaning that it involves the whole body and/or systems of the body. Currently, the North American medical community does not recognize the existence of systemic candida overgrowth in otherwise healthy subjects. Even though AIDS patients and those undergoing chemotherapy routinely suffer from the effects of yeast overgrowth, doctors claim there has been no valid research done on normal healthy subjects, and will tell you that any herbal or natural supplements used to fight a candida infection are a waste of time and money. Medical associations around the world have issued official statements on candidiasis hypersensitivity syndrome, and most are critical, claiming that, on the basis of the evidence so far reviewed, and until appropriate research published to the contrary is brought to their attention, the concept of Candidiasis is unproven, and the diagnosis, laboratory tests and treatments should be considered experimental, and reserved for use with informed consent in appropriate controlled trials that have been approved for scientific merit and safety by competent institutional review boardsYet a fairly substantial body of research exists from the 1950's that indicates researchers were aware of a growing problem associated with the widespread use of antibiotics, only ten years after its introduction into general clinical practice in 1944, a time when formerly deadly illnesses such as Strep throat and tuberculosis became instantly curable. The following research article outlines important work done by Huppert, and others, in the 1950's using in vivo techniques to demonstrate that broad-spectrum antibiotics, especially tetracycline, caused overgrowth of Candida albicans in lab animals, and hypothesized the results to human subjects. Pathogenesis of Candida albicans Infection Following Antibiotic Therapy. III. The Effect of Antibiotics on the Incidence of Candida Albicans in the Intestinal Tract of Mice . Journal of Bacteriology. 1955. Oct;70(4):440-7. M. Huppert, J. Cazin, Jr. and H. Smith, Jr. Department of Bacteriology and Immunology and Department of Biostatistics, University of North Carolina School of Medicine and School of Public Health, Chapel Hill, N.C. Ten years later, in 1966, an important research review article begins, Substantial clinical evidence has been accumulated, showing that candidiasis is a medical problem of increasing magnitude. That patients on antibiotics experience a proliferation of Candida albicans in the alimentary canal is no longer a point for dispute.Mechanisms by Which Antibiotics Increase the Incidence and Severity of Candidiasis and Alter the Immunological Defenses. Bacteriological Reviews, June 1966. Vol. 30, No. 2. Copyright © 1966 American Society for Microbiology. Mildred Seelig. Department of Pharmacology, New York Medical College, Flower and Fifth Avenue Hospitals, and Squibb International, New York, New York. In the late 1960's, the pharmaceutical companies began taking control of drug research. After this point, there is not much said on the topic until 1985 when Dr. Orian Truss published The Missing Diagnosis and a few years later with William Crook's popular book, The Yeast Connection. The books were scoffed, and most attempts by patients to talk to their physicians about the possibility of a candida infection have generally been 'laughed out of the office', and any products sold at health food stores have been considered to be snake oil by the mainstream medical community. The most recent developments in the story of Candida albicans involve researcher, Dr. Gregor Reid, a microbiologist at McMaster University in Hamilton, Ontario who has shown a great deal of interest in correcting dysbiosis with the administration of large doses of probiotics. More information will be added to this page as research beomes available. |
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